2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W779020
    Dihydrouracil-13C,15N2 181516-96-1 98%
    Dihydrouracil-13C,15N2 (5,6-Dihydrouracil-13C,15N2) is the 13C- and 15N-labeled Dihydrouracil (HY-W012926). Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient.
    Dihydrouracil-13C,15N2
  • HY-W779355
    cis-3,4-Di-p-anisyl-3-hexene-d6 89717-84-0 98%
    cis-3,4-Di-p-anisyl-3-hexene-d6 is the deuterium labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and?other?plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose.
    cis-3,4-Di-p-anisyl-3-hexene-d6
  • HY-W782193
    Sulcatone-d5 55320-91-7 98%
    Sulcatone-d5 (6-Methyl-5-hepten-2-one-d5) is the deuterium labeled Sulcatone (HY-W010435). Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
    Sulcatone-d5
  • HY-W823500
    GLP-1 Receptor modulator 1 1461715-47-8 98%
    GLP-1 Receptor modulator 1 (Compound 7) is a potent GLP-1 receptor positive allosteric modulator. GLP-1 Receptor modulator 1 can be used for the research of obesity and type 2 diabetes.
    GLP-1 Receptor modulator 1
  • HY-W926789
    (E)-GW7604 195611-82-6 98%
    (E)-GW7604 is the (E)-isomer of GW7604, an antiestrogen and a metabolite of GW5638 (HY-112746), which is a high-affinity estrogen receptor (ER) antagonist.
    (E)-GW7604
  • HY-W983015
    Davidigenin 23130-26-9 98%
    Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine.
    Davidigenin
  • HY-Y0289S2
    1-Dodecanol-d26 38086-03-2 98%
    1-Dodecanol-d26 is the deuterium labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.
    1-Dodecanol-d26
  • HY-Y0289S3
    1-Dodecanol-d1 14848-65-8 98%
    1-Dodecanol-d1 is the deuterium labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.
    1-Dodecanol-d1
  • HY-Y0319C1
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard 62-54-4 98%
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard (Calcium acetate (Pharmaceutical primary standard, USP)), a phosphate binder that can reduce phosphorus content, United States Pharmacopeia (USP) reference standard.
    Calcium acetate, United States Pharmacopeia (USP) Reference Standard
  • HY-Y0337AR
    L-Cysteine hydrochloride (Standard) 52-89-1
    L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF)[4].
    L-Cysteine hydrochloride (Standard)
  • HY-Y0337S7
    L-Cysteine-d3,15N 1795787-05-1 98%
    L-Cysteine-d3,15N is the deuterium and 15N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans.
    L-Cysteine-d3,15N
  • HY-Y0488AR
    Formic acid ammonium (Standard) 540-69-2
    Formic acid (ammonium) (Standard) is the analytical standard of Formic acid (ammonium). This product is intended for research and analytical applications. Formic acid ammonium salt is an endogenous metabolite.
    Formic acid ammonium (Standard)
  • HY-Y0504S1
    Trimethylammonium chloride-d10 107766-37-0 98%
    Trimethylammonium chloride-d10 is the deuterium labeled Trimethylammonium chloride. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-d10
  • HY-Y0504S2
    Trimethylammonium chloride-15N 108451-51-0 98%
    Trimethylammonium chloride-15N is the 15N labeled Trimethylammonium chloride. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-15N
  • HY-Y0546S2
    Benzophenone-13C 32488-48-5 98%
    Benzophenone-13C is the 13C labeled Benzophenone. Benzophenone is an endogenous metabolite.
    Benzophenone-13C
  • HY-Y0836S1
    Diethyl succinate-d4 52089-62-0 98%
    Diethyl succinate-d4 is the deuterium labeled Diethyl succinate. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring.
    Diethyl succinate-d4
  • HY-Y1809S1
    1-Hydroxyoctadecane-d2 86369-69-9 98%
    1-Hydroxyoctadecane-d2 is the deuterium labeled 1-Hydroxyoctadecane. 1-Hydroxyoctadecane is an endogenous metabolite.
    1-Hydroxyoctadecane-d2
  • HY-101064S1
    Fmoc-leucine-13C6,15N 1163133-36-5 98%
    Fmoc-leucine-13C6,15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity
    Fmoc-leucine-13C6,15N
  • HY-101400S1
    Deoxycytidine triphosphate-15N3,d14 dilithium 98%
    Deoxycytidine triphosphate-15N3,d14 (dCTP-15N3,d14 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3,d14) dilithium is deuterium and 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-15N3,d14 dilithium
  • HY-101400S2
    Deoxycytidine triphosphate-13C9,15N3 dilithium 98%
    Deoxycytidine triphosphate-13C9,15N3 (dCTP-13C9,15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9,15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-13C9,15N3 dilithium
Cat. No. Product Name / Synonyms Application Reactivity